Dear colleagues,

We are pleased to announce that the sixth Kiel Imaging Seminar (KIS) will take place next Monday, March 27th, 18h CET.    

We are much looking forward welcoming Prof. Helene Benveniste speaking on “Imaging glymphatic-lymphatic solute transport with MRI”. Cerebrospinal fluid (CSF) ‘flow’ dynamics in relation to glymphatic-lymphatic transport function will be a focus of her talk. 

Who: Prof. Helene Benveniste, Professor of Anesthesiology, Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA.

What: Expert lecture on “Imaging glymphatic-lymphatic solute transport with MRI.”

- Zhao et al. 2022, "Physiology of glymphatic solute transport and waste clearance from the brain." Physiology 37(6) (2022): 349-362.

- Chen et al. 2022, "Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries." Nature aging 2(3) (2022): 214-223.

When: Monday, March. 27th, 18h CET (GMT +1)

Where: https://uni-kiel.zoom.us/j/68086496919?pwd=UStXY0JxSjVKTnRXRjFkcnNTcVpCdz09  

Meeting-ID: 680 8649 6919, Passcode: 682584

About the presenter:

Helene Benveniste received her B.Sc. in Denmark majoring in Mathematics & Physics, and went on to the University of Copenhagen for her MD and PhD (Doctor Medicinae). As a Research Fellow she trained in high field magnetic resonance imaging (MRI) at Duke University Medical Center and developed techniques for brain imaging focused on neurodegenerative disease processes including Alzheimer’s Disease. She then went on to residency in Anesthesiology at Duke University. Dr. Benveniste started her own lab at Brookhaven National Laboratory in 2001, before moving to a faculty position in the Departments of Anesthesiology and Biomedical Engineering at Yale School of Medicine. Dr. Benveniste’s laboratory explores the functioning of the ‘glymphatic system’ – the waste disposal system of the brain.  Foremost, she and close scientific collaborators studies how the brain gets rid of toxic waste and she has developed imaging platforms to examine how cerebrospinal fluid (CSF) circulates in the brain and explored how several critical processes (e.g., body position, respiration, type of anesthesia, body position) impact waste removal across in healthy brain and in neurodegenerative diseases disease. The overall goal is to develop therapeutic strategies to sustain optimized waste clearance from through the given life span to prevent dementia.  She has received a number of honors including the Paul Beeson Physician Faculty Scholarship award; NYS Office of Science, Technology & Academic Research, Faculty Award; “Best Doctor in New York” Award 2009; and is an Elected Member, American College of Neuropsychopharmacology. Her research is supported by grants from the NIH, Cure Alzheimer’s Fund and the Leducq Foundation.

About the presentation:

Glymphatic brain waste disposal is a complex process involving multiple steps many of which remain incompletely understood. Essential for glymphatic waste disposal is the preservation of the central nervous system (CNS) fluid homeostasis and access to the meningeal lymphatic system and related draining lymph nodes. Recent evidence suggests that the meningeal lymphatic (mLV) network is anatomically distinct from the perineural lymphatics associated with cranial nerve outlets perhaps implying different outflow routes for ‘clean fluid’ versus fluid + brain waste. This is an important observation because fundamentally cerebrospinal fluid (CSF) ‘flow’ has been considered a biomarker for drainage of waste solutes as well as for the tight immune surveillance of the CNS. Although still debated, LVs along the cranial nerves are thought to perhaps serve as passive outflow for excess fluid to regulate CNS fluid homeostasis but with no bearing on waste disposal. Thus, a better understanding of the integrative and dynamic topology of CSF flow dynamics in relation to glymphatic-lymphatic transport function is needed. In my talk I will present and discuss MRI data from rodent studies focused on characterizing the cross-talk between the glymphatic and lymphatic systems. 

We are looking forward to meeting you!

Your Section Biomedical Imaging

Clinic for Radiology and Neuroradiology, University Hospital Schleswig-Holstein, Kiel University