Dear colleagues,

We are pleased to announce that the 7th Kiel Imaging Seminar (KIS) will take place on Monday, 24th of April 2023!

We are much looking forward welcoming Prof. Matthias van Osch speaking on “MRI for the study of the human brain clearance system (‘glymphatics’)”.  Ultra-high field MRI and combining arterial spin labeling MRI with a multi-echo readout will be a focus of his talk.

Who: Prof. Matthias van Osch, Professor of Radiology, Leiden University Medical Center, The Netherlands.

What: Expert lecture on “Ultra-high field MRI and arterial spin labeling MRI with a multi-echo readout in human brain clearance system (‘glymphatics’) studies.”

- Petitclerc et al. 2021, "Ultra-long-TE arterial spin labeling reveals rapid and brain-wide blood-to-CSF water transport in humans." Neuroimage 245 (2021): 118755.

- van Osch, Petitclerc & Hirschler 2022, "Probing cerebrospinal fluid mobility for human brain clearance imaging MRI: water transport across the blood-cerebrospinal fluid barrier and mobility of cerebrospinal fluid in perivascular spaces." Veins and Lymphatics 11.1 (2022).

When: Monday, April. 24th, 18h CET (GMT +1)

Where: https://uni-kiel.zoom.us/j/68086496919?pwd=UStXY0JxSjVKTnRXRjFkcnNTcVpCdz09 (Meeting-ID: 680 8649 6919, Passcode: 682584)

About the presenter:

Matthias van Osch, PhD. Professor of Radiology, Leiden University Medical Center, Leiden, The Netherlands and director of the C.J. Gorter MRI Center. Dr. Van Osch studied applied physics at the University Twente and obtained his PhD at Utrecht University on the topic of contrast agent perfusion MRI. After moving to Leiden, Prof. van Osch shifted his research to non-invasive perfusion MRI by means of arterial spin labeling and he became technical project leader for the installation of the first 7 Tesla MRI scanner in The Netherlands in 2007. His research centers around advanced physiological MRI methodology as well as high resolution anatomical neuroimaging. Recently, he became interested in human brain clearance imaging and is the PI of a JPND program on this topic. He is also actively involved in the ISMRM Neurofluids Studygroup.

About the presentation:

The rediscovery of a specialized brain clearance system (‘glymphatics’) along perivascular spaces in the 2010s, made it essential to develop MRI sequences to characterize this system. This presentation will focus on two different approaches to get information on human brain clearance and provide an overview of alternative techniques. Ultra-high field MRI with its higher SNR provides excellent possibilities to characterize the perivascular spaces in health and disease. Moreover, by adding motion-sensitizing gradients the mobility of the CSF in the perivascular spaces can be quantified. This allows us to study potential driving forces of CSF mobility, such as the cardiac and respiratory cycle and vasomotion. Moreover, with the recognition of the importance of perivascular clearance, it has become much more important to understand how water (CSF and ISF) is moving through the brain. By combining arterial spin labeling MRI with a multi-echo readout, it has previously been shown that the water transport across the blood-brain barrier can be measured. By extending this approach to longer echo-times, it becomes feasible to measure the water transport from the vascular into the CSF compartment. Such exchange does not only occur in the choroid plexus, but also in the subarachnoid space around the cortex.

We are looking forward to meeting you!

Your

Section Biomedical Imaging

Clinic for Radiology and Neuroradiology, University Medical Center Schleswig-Holstein, Kiel University